Tenants can be killed by hostile Monsters and NPCs, as well as environmental hazards. A good spread of interactive objects can keep them from bunching up.
While wandering around, Tenants will interact with each other and just about any object the player can interact with ( furniture, wired items, gongs, music players, teleporters, trash bins, etc), and many things the player can't (sinks, hand dryers, arcade games, tombstones, etc).
There are also unique Quest types to Tenants, generally focused on building new homes for even more Tenants, which have a higher chance of offering rare and exclusive objects as prizes. Most (but not all) Tenants also offer a variety of generated Quests, which can lead to Tenants requesting to join the player's Crew aboard their Ship.
Tenants have a wide variety of appearances and roles, and can be a valuable source of income and rare items, as a satisfied Tenant will pay various types of rent to the player over time. Tenants are a type of NPC spawned by placing a Colony Deed in a suitable room. A good assortment of Tenants can reap big rewards.